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We understand your concerns! E: gro. Received Nov 25; Accepted Apr 4. Studies have shown approximately that half of patients with CS have concomitant patent foramen ovale PFO , with clear data supporting paradoxical embolization as an aetiology of CS. This article is the first of a multi-part review and will detail the history of PFO closure and the clinical trials that have evaluated the efficacy of PFO device closure.
Data favour PFO closure in CS for reducing stroke in appropriate patients and should be considered as a treatment modality. Keywords: Clinical trials, cryptogenic stroke, Gartner Hype Cycle, patent foramen ovale, patent foramen ovale closure, patent foramen ovale device closure Cryptogenic stroke CS is a brain infarction that cannot be clearly attributed to cardioembolism, large-vessel atherosclerosis or small artery disease, despite extensive clinical evaluation.
Changes in pressure within the right atrium RA lead to instances of PFO, increasing the risk for passage of a paradoxical thrombus into the systemic circulation. Management of PFO with respect to reducing stroke is controversial. Here, we will review the history of PFO closure and the clinical trials that have evaluated the efficacy of PFO device closure.
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